规格：50µL/100µL
货号：PN0118
价格：1350元/50µL，2200元/100 µL
全称 | Tumor necrosis factor alpha |
别名 | TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor, Tumour necrosis factor alpha,tumor necrosis factor, TNLG1, TNF-α, TNF a, TNF alpha,NFα, TNF-α, Cachectin, TNFα.
|
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Mouse, Rat |
产品应用 | WB： 1: 200-1: 500IHC/IF: 1: 200-1: 800
|
理论分子量 | 26kDa |
细胞定位 | 细胞膜,分泌型蛋白 |
性 状 | Liquid |
浓 度 | 批次间有差异 |
免 疫 原 | KLH conjugated Synthetic peptide corresponding to Mouse TNF-alpha |
亚 型 | IgG |
纯化方法 | Affinity purification |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
TNF, as also known as TNF-alpha, or cachectin, is a mµLtifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circµLation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.
