规格：50µL/100µL
货号：PN0075
价格：1350元/50µL、2200元/100 µL
全称 | solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 |
别名 | Amino acid transport system xc, CCBR1, Cystine/glutamate transporter, SLC7A11, SLC7A11/xCT, xCT |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human(predicted: Human, Goat, Chicken) |
产品应用 | WB : 1:500-1:2000 IHC : 1:50-1:500 IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate FC : 0.80 ug per 10^6 cells in a 100 µl suspension |
理论分子量 | 55kDa |
细胞定位 | 细胞膜 |
性 状 | Liquid |
浓 度 | 500ug/ml |
免 疫 原 | SLC7A11/xCT fusion protein Ag25431 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
SLC7A11 (also known as xCT) is a membrane transporter involved in the uptake of cystine. It promotes glutathione synthesis through the uptake of cystine and the concomitant release of glutamate. This, in turn, protects cells from oxidative stress, maintains cellµLar redox balance, and prevents cell death induced by lipid peroxidation. SLC7A11 has been identified as a potential target for cancer therapeutics. It is overexpressed in mµLtiple malignant tumors and is closely associated with the growth, prognosis, metastasis, and treatment response of various cancers including lung cancer. 26864-1-AP recognizes the 55 kDa and 35-40 kDa protein similar to the paper published (PMID: 32188872, 19156441).
