规格：50µL/100µL
货号：PN0177
价格：1350元/50µL；2200元/100 µL
全称 | Keratin, type II cytoskeletal 8 |
别名 | KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO, keratin 8 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat |
产品应用 | WB 1:1500-1:1000 IHC/IF 1:200-1:1000 |
理论/实际分子量 | 54kDa |
细胞定位 | 细胞质 细胞核 |
性 状 | Liquid |
浓 度 | |
免 疫 原 | KLH conjugated Synthetic peptide corresponding to MouseCytokeratin 8
|
亚 型 | IgG |
纯化方法 | Affinity purification |
Uniprot ID | |
缓 冲 液 | Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
保存条件 | Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellµLar structural integrity and also functions in signal transduction and cellµLar differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
